Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.

Chen Zhang,Maoyu Wang,Yidie Ying,Fang Meng,Hongliang Gao,Shuxiong Zeng,Yasheng Zhu,Anwei Liu,Zhensheng Zhang,Chuanliang Xu

Cancer medicine（2023）

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摘要

KIF4A upregulation correlates with poor prognosis of UBC. Knockdown of KIF4A inhibits proliferation, migration, and invasion of UBC cells while inducing apoptosis possibly through dephosphorylation of AKT, changes in EMT-related genes, and interaction with YAP1.

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关键词

AKT serine/threonine kinase,Yes1 associated transcriptional regulator,kinesin family member 4A,urothelial bladder carcinoma

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