Early post-traumatic brain injury txa prevents blood brain barrier hyperpermeability and surrogates of neuroclinical recovery.

Matthew C Culkin,Priyanka Bele,Anastasia P Georges,Alfonso J Lopez, Grace Niziolek,Christina L Jacovides,Hailong Song,Victoria E Johnson,Lewis J Kaplan,Douglas H Smith,Jose L Pascual

The journal of trauma and acute care surgery（2023）

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摘要

Only early post-TBI TXA consistently improves murine neurological recovery. TXA preserves BBB integrity, but only when administered early. This effect appears independent of endothelial-leukocyte interactions and demonstrates a time-sensitive effect that supports only early TXA administration.

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