Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults.

Michael Malek-Ahmadi,Yi Su,Valentina Ghisays,Ji Luo,Vivek Devadas,Yinghua Chen,Wendy Lee,Hillary Protas,Kewei Chen,Henrik Zetterberg,Kaj Blennow,Richard J Caselli,Eric M Reiman

Alzheimer's research & therapy（2023）

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摘要

Plasma NfL concentrations are associated with the APOE ε4 allele, brain imaging biomarkers of neurodegeneration, and less good recall memory in CU late-middle-aged and older adults, supporting its value as an indicator of neurodegeneration in the preclinical study of AD.

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关键词

lower recall memory scores,apoe ε4 allele,neurodegeneration,plasma,brain imaging measurements,late-middle-aged

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