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The Subtilisin-Like Protease Furin Regulates Hemin-Dependent Ectodomain Shedding of Glycoprotein VI.

Annalena Fink,Anne-Katrin Rohlfing,Valerie Dicenta,David Schaale,Marcel Kremser,Zoi Laspa,Manuel Sigle,Xiaoqing Fu,Andreas Pelzer,Melina Fischer,Patrick Münzer,Tatsiana Castor,Karin Anne Lydia Müller,Oliver Borst,Michael Lämmerhofer,Meinrad Paul Gawaz

Thrombosis and haemostasis（2023）

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摘要
 In summary, we describe a novel mechanism of hemin-dependent GPVI shedding and platelet function mediated by furin.
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关键词
hemolysis, hemin, platelets, GPVI, shedding
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