Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology.

Rachael S Allen,Cara T Khayat,Andrew J Feola, Alice S Win,Allison R Grubman,Kyle C Chesler,Li He,Jendayi A Dixon,Timothy S Kern,P Michael Iuvone,Peter M Thule,Machelle T Pardue

Frontiers in neuroscience（2023）

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摘要

As shown previously, retinal deficits were detectable prior to cognitive deficits in GK rats. While retinal neuronal function was compromised, retinal vascular pathology was not observed, even at 12+ months. High endogenous levels of dopamine in the GK rat may be acting as an anti-angiogenic and providing protection against vascular pathology.

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关键词

Goto-Kakizaki,cognitive,diabetes,diabetic retinopathy,dopamine,electroretinogram,vascular

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