Cellular and humoral immunogenicity of the COVID-19 vaccine and COVID-19 disease severity in individuals with immunodeficiency.

C E Murray,C O'Brien, S Alamin,S H Phelan,R Argue, R Kiersey,M Gardiner, A Naughton, E Keogh, P Holmes,S Naughton,A Scanlon, A Sloan, P McCrea, J Sui, J Dunne,N Conlon

Frontiers in immunology（2023）

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摘要

Covid whole-blood IGRA is a highly accurate, straightforward and robust assay and can be easily adapted to measure cellular response to COVID-19. A complete evaluation of the vaccine response may be particularly important for individuals living with immunodeficiency. A clinical immunodeficiency score and a validated vaccine response score may be valuable tools in estimating COVID-19 disease risk and identifying individuals living with immunodeficiency who may benefit from enhanced vaccination schedules.

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关键词

COVID-19 vaccination,IGRA methods,clinical scoring systems,immunodeficiencies affecting cellular and humoral immunity,spike protein specific ELISA

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