Targeting NK-1R attenuates renal fibrosis via modulating inflammatory responses and cell fate in chronic kidney disease.

Enyi Zhu,Yang Liu,Ming Zhong,Yu Liu,Xi Jiang,Xiaorong Shu,Na Li,Hui Guan,Yin Xia,Jinhong Li,Hui-Yao Lan,Zhihua Zheng

Frontiers in immunology（2023）

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摘要

Our data reveals that SP/NK-1R signaling promotes renal inflammatory responses and fibrosis, suggesting NK-1R could be a potential therapeutic target for the patients with CKD.

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关键词

NK-1R,chronic kidney disease,macrophages,neuropeptide,renal fibrosis,renal inflammation,substance P,targeted therapy

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