What endocrinologists can do to prevent cardiovascular complications in adults with Prader-Willi syndrome: Lessons from a case series.

Karlijn Pellikaan,Paula M H van Weijen,Anna G W Rosenberg,Franciska M E Hoekstra, Michiel Vermaak, Peter H N Oomen,Aart J van der Lely,Judith A A E Cuypers,Laura C G de Graaff

Frontiers in endocrinology（2023）

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摘要

Diagnosing CV problems in PWS adults is challenging. Peripheral edema is common in PWS adults without CV morbidity, which makes edema in general a poor marker for heart failure. However, when edema is of the pitting kind and progressive, this is a strong predictor of cardiac decompensation. We provide practical recommendations for diagnosing and treating CV problems in this vulnerable patient population.

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Prader-Willi syndrome,cardiovascular abnormalities,cardiovascular system,comorbidity,heart failure

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