Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity.

Yu Peng,Yi Huan,Jing-Jing Chen,Tian-Jiao Chen,Lei Lei,Jin-Ling Yang,Zhu-Fang Shen,Ting Gong,Ping Zhu

Frontiers in microbiology（2023）

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摘要

Our work presents that 3--MG PIC (), obtained by microbial transformation, is an effective and safer ligand targeting GPR119, which lays a foundation for the anti-diabetic drug design in the future.

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关键词

Beauveria bassiana,GPR119 agonist,insulin secretion,methylglucosylation,microbial transformation,stilbenes

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