Antihepatoma peptide, scolopentide, derived from the centipede scolopendra subspinipes mutilans.

Yu-Xing Hu,Zhuo Liu,Zhen Zhang,Zhe Deng,Zhen Huang,Ting Feng,Qing-Hong Zhou,Si Mei,Chun Yi,Qing Zhou,Pu-Hua Zeng,Gang Pei,Sha Tian,Xue-Fei Tian

World journal of gastroenterology（2023）

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摘要

Scolopentide, an antihepatoma peptide purified from centipedes, may inspire new antihepatoma agents. Scolopentide activates DR4 and DR5 and induces apoptosis in liver cancer cells through a mitochondria-independent pathway.

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关键词

Antihepatom peptide,Centipede,Death receptor 4,Death receptor 5,Hepatocellular carcinoma,Scolopendra

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