Somatostatin Interneurons in Emotion Regulation

Ekaterina Likhtik, Joseph Stujenske,Pia-Kelsey O'Neill,Carolina Fernandes-Henriques,Itzick Nahmoud, Samantha Goldburg,Ashna Singh,Laritza Diaz,Margarita Labkovich,William Hardin,Scott Bolkan,Thomas Reardon,Timothy Spellman, Daniel Saltzman,Conor Liston,Joshua Gordon

Biological Psychiatry（2023）

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摘要

Somatostatin-interneurons (SST-INs) maintain inhibitory-excitatory balance in microcircuits throughout the brain. SST-IN activity in the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) has been studied during fear learning. However, we investigated the role of BLA SST-INs in learning non-aversive cues and fear suppression, which is not well understood, but is critical to combat generalized fear in psychiatric disorders.

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emotion regulation

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