Effect of reduced two-dose (1+1) schedule of 10 and 13-valent pneumococcal conjugate vaccines (SynflorixTM and Prevenar13TM)) on nasopharyngeal carriage and serotype-specific immune response in the first two years of life: Results from an open-labelled randomized controlled trial in Indian children

Anand Kawade,Girish Dayma,Aditi Apte, Nilima Telang, Meenakshi Satpute,Emma Pearce,Lucy Roalfe,Rakesh Patil, Yanyun Wang,Navideh Noori, Arun Gondhali,Sanjay Juvekar,Assaf P. Oron,Sonali Sanghavi,David Goldblatt,Ron Dagan,Ashish Bavdekar

Vaccine（2023）

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摘要

The reduced dose schedule (1 + 1) of PCV13 results in significant VT-carriage reduction in the second year of life. Immune protection provided by 1 + 1 schedules of PCV10 and PCV13 in the second year of life is comparable to WHO-recommended 3-dose schedules.

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Pneumococcal carriage,Pneumococcal conjugate vaccines,Reduced dose regime,Serotype-specific antibodies

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