Schisandrin A ameliorates increased pulmonary capillary endothelial permeability accompanied with sepsis through inhibition of RhoA/ROCK1/MLC pathways.

Li-Juan You, Pei-Wei Li,Wen-Wen Zhang, Ming-Feng Feng, Wei-Ping Zhao, Hui-Min Hou, Xian-Mei Piao,Li-Bo Wang,Yan Zhang

International immunopharmacology（2023）

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摘要

In summary, our results indicate that SchA ameliorates the increase of pulmonary endothelial permeability induced by sepsis through inhibition of RhoA/ROCK1/MLC pathway, providing a potentially effective therapeutic strategy for sepsis.

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关键词

Acute lung injury,RhoA/ROCK1/MLC,Schisandrin A,Vascular permeability

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