The Ethyl acetate extract from Celastrus orbiculatus suppresses non-small-cell lung cancer by activating Hippo signaling and inhibiting YAP nuclear translocation.

Feng Jin,Xiaochen Ni,Shilong Yu,Xiaomin Jiang,Xinlin Shi,Jun Zhou, Defang Mao,Haibo Wang,Yanqing Liu,Feng Wu

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

This study demonstrated that COE inhibited NSCLC through activating Hippo signaling and suppressing YAP nuclear translocation, in which ROS may play a role in the phosphorylation of the MOB1 protein.

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关键词

Celastrus orbiculatus extract,Cellular bioenergetics,Hippo signaling,Non-Small-Cell Lung Cancer,YAP

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