Psychosocial health modifies associations between HPA-axis function and brain structure in older age.

Isabelle F van der Velpen,Maud de Feijter, Rutika Raina,Fatih Özel,Marieke Perry,M Arfan Ikram,Meike W Vernooij,Annemarie I Luik

Psychoneuroendocrinology（2023）

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摘要

Diminished function of the HPA-axis is differently associated with brain structure in community-dwelling middle-aged and older adults with clinically relevant depressive symptoms or suboptimal social support, but not in adults without depressive symptoms or with optimal social support.

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关键词

Brain structure,Depression,Dexamethasone suppression test,HPA-axis,Magnetic resonance imaging,Social support

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