Safety and Efficacy Results from iSABR, a Phase I Study of Stereotactic Ablative Radiotherapy (SABR) in Combination with Durvalumab for Early-Stage Medically Inoperable Non-Small Cell Lung Cancer (NSCLC).

For early-stage NSCLC, combination SABR and durvalumab resulted in excellent disease specific outcomes. Safety appeared acceptable per protocol, but 5/18 patients experienced Grade ≥3 pulmonary toxicity including one Grade 5 event in a patient with ILD. Results support ongoing phase III trials determining the benefit of SABR and immune check point inhibitors in this population.