Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer.

Noor Shakfa,Deyang Li,Gwenaelle Conseil,Elizabeth D Lightbody,Juliette Wilson-Sanchez,Ali Hamade,Stephen Chenard,Natasha A Jawa,Brian J Laight,Afrakoma Afriyie-Asante,Kathrin Tyryshkin,Martin Koebel,Madhuri Koti

Journal for immunotherapy of cancer（2023）

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摘要

This study reveals the importance of considering the influence of cancer cell intrinsic genetic alterations on the TIME for therapeutic selection. We establish the rationale for the optimal incorporation of interferon activating therapies as a novel combination strategy in PTEN-deficient HGSC.

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关键词

Genital Neoplasms, Female,Immunomodulation,Immunotherapy,Interferon Inducers,Tumor Microenvironment

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