Copper-Catalyzed Synthesis of beta-Alkynyl Ketones from Propargylic Alcohols and Enamides

An efficient method to access beta-alkynyl ketones from propargylic alcohols and enamides under copper catalysis was developed. This methodology allows access to a series of highly functionalized beta-alkynyl ketones in moderate to excellent yields under mild conditions. Moreover, the resultant products could further be transformed to various valuable scaffolds with potential biological activities.