Potential indicators for hyperparathyroidism progression: Calcium, phosphorus, alkaline phosphatase, 25 hydroxyvitamin D and hemoglobin

Purpose: To compare the differences in perioperative biochemical indices between patients with primary hyperparathyroidism (PH) and secondary hyperparathyroidism (SH). Methods: One hundred and ten patients with hyperparathyroidism who were treated in The Affiliated Hospital of Chengde Medical University, from June 2016 to April 2021, were enrolled and divided into two groups, viz, PH group (50 patients) and SH group (60 patients). Automatic biochemical analyzer was used to determine the levels of calcium, phosphorus, alkaline phosphatase and 25-hydroxyvitamin D, while hemoglobin was determined by liquid chromatography coupled with tandem mass spectrometry in the perioperative period. Results: Compared to PH group, SH group had higher levels of indicators (p < 0.05). There were significant differences in body mass index (BMI), somatic cell index and blood albumin in patients from 18 to 70 years (p < 0.05). BMI and blood albumin increased significantly with age (p < 0.05). The complication rate was higher in SH than PH group (p < 0.05). The scores of pruritus and bone pain of patients after surgery were lower than those before the operation (p < 0.05). Blood calcium levels increased significantly with age, while ALP and iPTH levels decreased significantly (p < 0.05). SH group showed lower scores of physiological, emotional, social, and cognitive functions than PH group (p < 0.05). Conclusion: Patients with PH and SH have differences in perioperative biochemical indicators. Furthermore, the levels of calcium, phosphorus, alkaline phosphatase, 25 hydroxyvitamin D, and hemoglobin may be used as indicators of disease progression, and this may facilitate the development of suitable therapeutic measures.