Flicking the switch in myeloma MRD

BLOOD(2023)

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摘要
In this issue of Blood, Paiva et al1 report that serial monitoring of measurable residual disease (MRD) during maintenance treatment of multiple myeloma (MM) captures dynamic conversion between negative (MRD-) and positive (MRD+) states and robustly anticipates progression-free survival (PFS). They show the feasibility of longer-term MRD monitoring and provide a rationale for trials that investigate intervention before frank relapse.
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