Research Progress in Application of Metal-organic Frameworks in Surface-enhanced Raman Spectroscopy

Metal-organic frameworks (MOFs), which are self-assembled by metal ions and organic ligands through coordination chemistry, have periodically lattice crystalline porous structure, and have been widely used as materials due to their unique structures and properties. Because MOFs can greatly improve the target enrichment and signal enhancement performance of metal surface-enhanced Raman spectroscopy (SERS) substrates, MOFs- based SERS substrates have attracted much attention. The efficient SERS substrate enables SERS technology achieves high sensitivity, high selectivity, nondestructive and rapid detection. The advantages of MOFs and SERS greatly promote the development of SERS technology and widen its application range. In this review, the development of SERS, MOFs based substrate categories and their applications in SERS were reviewed, the key issues to be solved urgently and challenges were discussed, and the future development trend was prospected.