Efgartigimod restores muscle function in a humanized mouse model of immune-mediated necrotizing myopathy.

Sarah Julien,Bas van der Woning, Leentje De Ceuninck,Emma Briand, Thara Jaworski,Gaëlle Roussel,Rachid Zoubaïri,Yves Allenbach,Olivier Benveniste,Laurent Drouot,Olivier Boyer

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY（2023）

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摘要

Efgartigimod reduces circulating IgG levels, including pathogenic anti-HMGCR+ IgG aAbs in a humanized mouse model of IMNM, preventing further necrosis and allowing muscle fiber regeneration. These results support investigating the therapeutic efficacy of efgartigimod through a clinical trial in IMNM patients.

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关键词

autoantigens and autoantibodies, myositis and muscle disease, muscle, animal models, immunotherapy

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