Tumor-targeted nano-adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity

Photomediated immunotherapy explored to combine the anti-cancer effect of phototherapy with the immune enhancement ability of immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated immunotherapy triggered antitumor immunity through the release of tumor antigens and damage-associated molecular patterns from necrotic tumor cells was not enough mighty to improve the therapeutic benefits due to the immunosuppressive tumor microenvironments. Herein, a tumor-targeted nano-adjuvant Fucoidan@Al(OH)(3)-Poly(I:C)/IR-820 for tumor-targeted therapy and metastasis inhibition was designed and prepared. The intrinsic immunomodulatory effects of tumor-targeted nano-adjuvant and their ability to simultaneously trigger tumor antigen release, thereby reversing immunosuppression and achieving potent antitumor immunity and augmented cancer therapy, were explored. The results proved that the multifunctional nano-adjuvant combined with photothermal, photodynamic, and immunotherapy could effectively treat breast cancer and had metastasis inhibition effect by enhancing anti-tumor immunity through immunomodulation, it should have great application potential in the treatment of breast cancer.