Brimonidine eye drops reveal diminished sympathetic pupillary tone in comatose patients with brain injury.

Elisabeth Waldemar Jakobsen,Vardan Nersesjan,Simon Sander Albrechtsen,Marwan H Othman,Moshgan Amiri,Niels Vendelbo Knudsen,Merlin D Larson,Christian Hassager,Kirsten Møller,Jesper Kjaergaard,Daniel Kondziella

Acta neurochirurgica（2023）

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摘要

In this proof-of-principle study, brimonidine eye drops produced anisocoria in awake volunteers but not in comatose patients with brain injury. This suggests that automated pupillometry after administration of brimonidine can distinguish between the extremes of the spectrum of consciousness (i.e., fully conscious vs. deeply comatose). A larger study testing the "intermediate zone" of disorders of consciousness in the ICU seems warranted.

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关键词

Automated pupillometry,Cardiac arrest,Coma,Consciousness,Disorders of consciousness,Prognosis,Traumatic brain injury

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