Figure S2: Sensitivity to FAK inhibition under anchorage-independent conditions in a panel of thyroid cancer cells. from FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes

Viability of thyroid cancer cells treated with 1µM PF-573,228 for 6 days was normalized to DMSO-treated cells, set to 100%. Results are % viable cells per mL {plus minus} SD of at least 2 experiments performed in triplicate (t-test: C643, K1, THJ11T: p{less than or equal to}0.05; TPC1 PF-573: p{less than or equal to}0.01; all others p=n.s.). (B) Colonies of thyroid cancer cells treated with 1µM PF-573,228 in soft agar were allowed to form for 20 days and normalized to DMSO-treated cells, set to 100%. Results shown are percent of colony formation {plus minus} SD of 2 independent experiments performed in duplicate (t-test: TPC-1 PF-573: p{less than or equal to}0.001; C643 PF-573: p{less than or equal to}0.001; K1 PF-573: p{less than or equal to}0.001).