Reward disturbances in antipsychotic-naïve patients with first-episode psychosis and their association to glutamate levels.

Karen Tangmose,Egill Rostrup,Kirsten B Bojesen,Anne Sigvard,Kasper Jessen,Louise Baruël Johansen,Birte Y Glenthøj,Mette Ødegaard Nielsen

Psychological medicine（2023）

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摘要

Our findings confirm prior findings of abnormal outcome evaluation as a part of the pathophysiology of schizophrenia. The results also suggest a possible link between thalamic glutamate and NOE signaling in patients with first-episode psychosis.

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关键词

Functional magnetic resonance imaging,motivational salience,outcome evaluation,schizophrenia,spectroscopy

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