Isorhamnetin induces cell cycle arrest and apoptosis by triggering DNA damage and regulating the AMPK/mTOR/p70S6K signaling pathway in doxorubicin-resistant breast cancer

Tianshu Yang,Yi Xiao, Shuo Liu,Fazhen Luo,Dongyun Tang, Yilin Yu,Yan Xie

Phytomedicine（2023）

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摘要

•Isorhamnetin (IS) alleviated the resistance of breast cancer to doxorubicin.•IS inhibited cell proliferation and migration of drug-resistant cells.•IS induced cell cycle arrest and apoptosis by triggering DNA damage.•IS caused AMPK-mediated interruption of the mTOR/p70S6K signaling pathway.

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关键词

isorhamnetin,breast cancer,apoptosis,doxorubicin-resistant

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