DNMT1 mediates chronic pain-related depression by inhibiting GABAergic neuronal activation in central amygdala.

Xiaobao Ding,Yuwen Lin,Chen Chen,Binbin Yan, Qiang Liu,Hui Zheng,Yuqing Wu,Chenghua Zhou

Biological psychiatry（2023）

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摘要

Our findings suggest DNMT1 is involved in the development of chronic pain-related depression by epigenetic repression of GAD67, leading to the inhibition of GABAergic neuronal activation. This study indicates that DNMT1 could be a potential target for the treatment of chronic pain-related depression.

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关键词

Chronic pain,DNMT1,GABAergic neurons,GAD67,central amygdala,depression

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