Supplementary Online Content from Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE)

Figure S1. Population Admixture Revealed by STRUCTURE Analysis Figure S2. Distribution of Polygenic Risk Score among Female Survivors of European Ancestry Figure S3. Cumulative Incidence of Subsequent Breast Cancer Differs by Polygenic Risk Score after Excluding Breast Cancer Predisposing Mutation Carriers Table S1. Previously Reported Loci Associated with Overall Breast Cancer Table S2. Polygenic Risk Score for 1133 Female Childhood Cancer Survivors of European Ancestry Table S3. Quintile Cutoffs for Polygenic Risk Score Based on 1133 Female Survivors or Estimated with Minor Allele Frequencies within OncoArray Control Population Table S4. Pathogenic or Likely Pathogenic Mutations in 11 Breast Cancer Predisposition Genes for 1133 Female Survivors of European Ancestry Table S5. Baseline Risk Model for Subsequent Breast Cancer Table S6. Association of Polygenic Risk Score with Rate of Subsequent Breast Cancer in Survivors of Childhood Cancer after Excluding Predisposing Mutation Carriers Table S7. Association of Polygenic Risk Score with Rate of Subsequent Breast Cancer in Survivors of Childhood Cancer after Excluding Predisposing Mutation Carriers (top 10% of PRS)