Supplementary Figure 4 from VEGF Regulates Region-Specific Localization of Perivascular Bone Marrow–Derived Cells in Glioblastoma

PDF file - 1139KB, At early stages of tumor growth BMDCs exist in a differentiated state through the central and peripheral regions. At later stages the differentiated BMDCs are lost in the vasculature in the central regions but retained in the periphery (A). Following inhibition of VEGF through direct drug therapy, VEGFtrap (C), or indirectly, RTx (B), there is a compensatory up-regulation of ANG2, which in turn initiates the recruitment of differentiated BMDCs back to central vessels.