Supplementary Figures 1 - 6 from Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors

PDF file - 816KB, Confirmation of CpG island hypermethylation patterns by COBRA DNA methylation analysis (S1). Reproducibility of chromatin immunoprecipitation from frozen human tissue samples (S2). Loss of H3K27me3 in colorectal cancer and mutually exclusive gain of 5mC or H3K4me3 (S3). Bivalent genes in human colonic mucosa (S4). H3K27me3 patterns in human colonic mucosa and aberrant DNA methylation in colorectal cancer (S5). Cancer-associated transcriptional changes at bivalent promoters (S6).