Supplementary Figures 1-6 from Chromosome Instability Modulated by <i>BMI1–AURKA</i> Signaling Drives Progression in Head and Neck Cancer

PDF file -810KB, Twist1 upregulates Bmi1 and aurora kinase A expression, and co-amplification of BMI1 and AURKA in CD44+ HNSCC cells (S1); Akt pathway and let-7i repression are two independent mechanisms induced by Bmi1 to regulate aurora kinase A expression (S2); Suppression of Bmi1 or aurora kinase A reduces centrosomal amplification, aneuploidy, reduces p53 serine 315 phosphorylation and stabilizes p53 in OECM-1 cells (S3); Knockdown of aurora kinase A represses EMT, and overexpression of aurora kinase A is sufficient to induce EMT (S4); The influence of aurora kinase A on the expression of different EMT regulators (S5); Aurora kinase A increases GSK-3� phosphorylation and interacts with GSK-3� in HNSCC cell lines (S6)