Supplementary Tables 1 - 2 from Intratumoral Modeling of Gefitinib Pharmacokinetics and Pharmacodynamics in an Orthotopic Mouse Model of Glioblastoma

PDF file - 94K, Supplementary Table S1. PK parameters of gefitinib in plasma, normal brain and brain tumor in U87VIII intracerebral tumor bearing athymic mice receiving single oral 50 mg/kg and 150 mg/kg doses of gefitinib. Parameters were obtained by noncompartmental analysis of data from all the mice (n=3 at each time point) at each dose level. Supplementary Table S2. Intratumoral variability in gefitinib concentrations in LN229VIII-PTEN Brain Tumor Model in Mice Following a Single Oral Dose of 150mg/kg.