Supplementary Figure 6 from Chk2 Phosphorylation of Survivin-ΔEx3 Contributes to a DNA Damage–Sensing Checkpoint in Cancer

PDF file - 271K, Correlation between survivin and activated Chk2 expression during colorectal tumorigenesis, in vivo. A. Patient-derived surgical or endoscopic specimens representative of progressive stages of the colorectal adenoma-to-carcinoma transition (normal mucosa, hyperplasia, moderate dysplasia, severe dysplasia and adenocarcinoma) were analyzed for expression of Thr68-phosphorylated (T68) Chk2, survivin, p53, or Chk2, by immunohistochemistry. B. Tissue slides representative of the indicated histologic diagnoses (20 cases/each) were scored for positively stained cells using a 5% cutoff. IHC, immunohistochemistry.