Supplementary Figure S4 from Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma

Supplementary Figure S4. A. BX-912 shows no cross-resistance with BTZ. BX-912 exerted its growth inhibitory effect on BTZ-resistant KMS-11/BTZ cells and OPM-2/BTZ cells (red lines) as effectively as on their respective parental cells (blue dotted lines). Cells were treated with the indicated concentrations of either BX-912 or BTZ for 48 hours. The viable cell number of untreated cells was considered to be 1.0. B. The combination of BX-912 and the NF-κB inhibitor, BAY11-7085, exhibited an additive growth inhibitory effect on BTZ-resistant KMS-11/BTZ cells and OPM-2/BTZ cells. Shaded areas represent the additive effects of the two agents.