Supplementary Figures 1-5, Table 1 from <i>In Vivo</i> Regulation of TGF-β by R-Ras2 Revealed through Loss of the RasGAP Protein NF1

PDF file - 488K, Insertion into the mouse TC21 gene causes a null allele. Supplemental Table 1. Loss of TC21 partially rescues Nf1 mutant embryonic lethality. Supplemental Figure 2: Loss of TC21 decreases the survival of NPCis mice by increasing brain tumors. Supplemental Figure 3. Cell death in spheres and TGFbeta1 expression in sciatic nerves and neurofibromas. Supplemental Figure 4: Nf1-/- DRGs and spheres express high levels of phospho-AKT but not phospho-SMAD2/3. Supplemental Figure 5: Expression of TGFbeta ligands and receptors in mouse MPNST and human MPNST cell lines