A high-throughput drug screening identifies luteolin as a therapeutic candidate for pathological cardiac hypertrophy and heart failure.

Zhenya Wang,Wei Shi,Taibo Wu, Tian Peng,Xiaoming Wang,Shuaiyang Liu,Zifeng Yang,Jia Wang,Peng-Long Li,Ruifeng Tian,Ying Hong,Hailong Yang,Lan Bai,Yufeng Hu,Xu Cheng,Hongliang Li,Xiao-Jing Zhang,Zhi-Gang She

Frontiers in cardiovascular medicine（2023）

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摘要

Our data clearly supported that luteolin is a promising therapeutic compound for pathological cardiac hypertrophy and heart failure by directly targeting ubiquitin-proteasomal degradation of PPARγ and the related metabolic homeostasis.

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关键词

cardiac hypertrophy,fatty acid metabolism,glucose metabolism,heart failure,luteolin,peroxisome proliferator activated receptor γ

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