Primary Aldosteronism Prevalence - An Unfolding Story.

Primary aldosteronism (PA) is characterized by dysregulated, renin-independent aldosterone excess. Long perceived as rare, PA has emerged as one of the most common causes of secondary hypertension. Failure to recognize and treat PA results in cardiovascular and renal complications, through processes mediated by both direct target-tissue insults, and indirectly, by hypertension. PA spans a continuum of dysregulated aldosterone secretion, which is typically recognized in late stages, after treatment-resistant hypertension and cardiovascular and/or renal complications develop. Determining the precise disease burden remains challenging, due to heterogeneity in testing, arbitrary thresholds, and populations studied. In this review, we summarize the reports on PA prevalence among the general population and in specific high-risk subgroups, highlighting the impact of rigid versus permissive criteria on PA prevalence perception.