Supplementary figures and figure legends from APC/C-CDH1–Regulated IDH3β Coordinates with the Cell Cycle to Promote Cell Proliferation

Fig S1. The changing trend of α-KG, fumarate and malate were significantly correlated with S phase.Fig S2. IDH3β accumulated in late G1 phase and CDC20 was not the regulator of IDH3β. Fig S3. The interaction of IDH3β and CDH1 was strong in G1 and weak in G2/M. Fig .S4 IDH3β regulated the G1/S transition and cell proliferation. Fig .S5 Xenograft tumor formation of stable IDH3β overexpressed KYSE410 cells and control cells.Fig .S6 IDH3α, IDH3β and IDH3γ contribute to oxidative metabolism in TCA cycle.Fig .S7 IDH3β-dependent α-KG generation accounts for improving cell proliferation. Fig .S8 IDH3β enhances cytoplasmic PFKFB3 level in IDH3β overexpressed cell.