Supplementary Methods, Supplementary Figures 1-5 from Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models

Supplementary Methods; Figure S1: Immunoblot and immunofluorescence analysis of MET and HGF in TNBC and fibroblast cell lines. Figure S2: Met inhibition has minimal effect on ERK5 signaling in human TNBC cells. Figure S3: XL184 and U0126 significantly reduce volume and outgrowths of MDA-MB-231 structures. Figure S4: Minimal growth recovery is observed after XL184 removal Figure S5: MET inhibition in C3H-SCID mice.