Supplemental Figure S8 from Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1

Supplemental Figure S8. MMTV-Neu tumors were measured on treatment day 1 and again on treatment day 29. measurements from each tumor is represented by a datapoint. The line connects measurements from a single tumor on day 1 to the measurement of the same tumor on day 29. Vehicle-treated tumors are shown in gray. A. Vehicle-treated tumors are compared to tumors treated with lapatinib (shown in black). B. Vehicle-treated tumors are compared to tumors treated with BMS-777607 + Epacadostat (B/E, shown in red). C. Vehicle-treated tumors are compared to tumors treated with Lapatinib + BMS-777607 + Epacadostat (L/B/E, shown in blue). D. Vehicle-treated tumors are compared to all remaining treatment groups: lapatinib-treated tumors in black, B/E-treated tumors in red, and L/B/E-treated tumors in blue.