Practical R-R Interval Editing for Heart Rate Variability Analysis Using Single-Channel Wearable ECG Devices.

Recent innovations in wearable devices have expanded the usage opportunities of single-channel electrocardiography (ECG) recordings in a daily life environment and enabled a variety of indirect daily activity monitoring based on heart rate variability (HRV). In general, wearable ECGs rarely undergo visual inspection by medical experts and therefore may contain noise or artifacts. Although noise/artifact-induced changes in ECG waveforms are known to cause misdetection of the QRS complex (i.e., the most distinguishable ECG components comprised of Q wave, R wave, and S wave), its complete suppression might be technically impossible. Since misdetection occurs in the QRS complex unit, we propose reframing the traditional HRV analysis flow by subdividing the R-R interval (RRI) editing into four steps in accordance with the processing detail (i.e., identification and editing) and its target unit (i.e., QRS complex or RRI). In addition, as a dubious QRS complex identification method for practical use, we utilize the amplitude at the detected point assuming the use of a single-channel wearable ECG without a reference. Initial evaluations using pseudo/real ECG datasets including ECGs with noise/artifacts show that the proposed processing/unit-based subdivision is theoretically effective for improving HRV calculation accuracy, and that the dubious QRS complex identification method for practical use also maintains this effect. Our study starting from practical HRV analysis using single-channel wearable ECG devices encourages reexamining each step in HRV analysis through the interdisciplinary research of clinical medicine and engineering/informatics that reveals the relationship of every two adjacent steps from the perspective of theory and practice.