Fascicle-Selective Bidirectional Peripheral Nerve Interface IC with 173dB FOM Noise-Shaping SAR ADCs and 1.38pJ/b Frequency-Multiplying Current-Ripple Radio Transmitter.

The peripheral nervous system (PNS) provides a conduit through which organs can communicate with the central nervous system. PNS neural interfaces have been deployed in open-loop fashion to help restore motor or sensory functions in paralyzed or amputated individuals, and also as implantable closed-loop therapeutic devices for treating chronic medical conditions related to autoimmune or metabolic disorders. Their efficacy and the scope of clinical use, however, are severely curtailed by the invasiveness of the cable, electronics and battery, and the lack of nerve fascicle selectivity and online adaptivity. We present a battery-free wireless PNS interface that features a mm-scale fascicle-selective neural interface IC with extraneural recorders and stimulators, as well as a wearable interrogator with integrated machine learning (ML) to enable adaptive neuromodulation therapy with low invasiveness.