Biomarkers of oxidative stress and its nexus with haemoglobin variants and adverse foeto-maternal outcome among women with preeclampsia in a Ghanaian population: A multi-centre prospective study.

Ganiwu Abdul, William Osei-Wusu,Gordon Akuffo Asare,Samira Daud,Stephen Opoku,Valentine Christian Kodzo Tsatsu Tamakloe,Joseph Frimpong,Benedict Sackey,Wina Ivy Ofori Boadu,Vivian Paintsil,Max Efui Annani-Akollor,Yaw Amo Wiafe,Enoch Odame Anto,Otchere Addai-Mensah

PloS one（2023）

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摘要

Reduced levels of vitamin C are common among preeclamptics with at least one copy of the HbC variant. Haemoglobin variants in preeclampsia contribute to adverse foeto-maternal outcomes with Haemoglobin S variants being the most influencing factor for PPH, HELLP, preterm labour, NICU admission, and neonatal jaundice.

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preeclampsia,oxidative stress,haemoglobin variants,biomarkers,foeto-maternal,multi-centre

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