Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1.

Eri Asami,Megumi Kitami,Takako Ida,Tadaharu Kobayashi,Makio Saeki

Immunopharmacology and immunotoxicology（2023）

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摘要

2M4VP induces Keap1 degradation and promotes Nrf2 nuclear translocation. Activation of Nrf2/ARE pathway enhances HO-1 expression and leads to iNOS inhibition for anti-inflammatory function.

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关键词

2-Methoxy-4-vinylphenol,anti-inflammatory,antioxidant,heme oxygenase-1,inducible nitric oxidase synthase

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