The safety and immunogenicity of a two-dose schedule of CoronaVac, and the immune persistence of vaccination for six months, in people living with HIV: A multicenter prospective cohort study.

Yuxiao Wang,Ying Qiao,Yuqi Huo,Li Wang, Shijie Liang,Maohe Yu,Xinquan Lan,Moxin Song,Xiangjun Zhang,Ying Yan,Junjie Xu

Frontiers in immunology（2023）

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摘要

The Sinovac CoronaVac was generally safe and immunogenic in PLWH, but the immunity response was inferior and the antibodies vanished faster compared to HIV-negative individuals. This study suggested a shorter than 6-month interval of prime-boost vaccination for PLWH to ensure a better protection.

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关键词

PLWH,S-IgG antibody,Sinovac CoronaVac,adverse events,neutralizing antibody

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