Impact of Previous Common Human Coronavirus Exposure on SARS-CoV-2-Specific T-Cell and Memory B-Cell Response after mRNA-Based Vaccination.

José L Casado,Pilar Vizcarra,Adrián Martín-Hondarza,Magdalena Blasco,Marta Grandal-Platero,Johannes Haemmerle,Marina Fernández-Escribano,Alejandro Vallejo

Viruses（2023）

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摘要

While pre-existing T-cell cross-reactivity enhances the T-cell response after vaccination, it does not increase SARS-CoV-2-specific MBC levels in the absence of previous infection. Overall, the level of specific MBCs determines the time to breakthrough infections, regardless of the presence of T-cell cross-reactivity.

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关键词

SARS-CoV-2,coronavirus,cross-reactive,mRNA vaccine,memory B-cells

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