Role of profilin-1 in vasculopathy induced by advanced glycation end products (AGEs).

Qiying Xie,Liping Ma,Zhilin Xiao,Mei Yang,Meifang Chen

Journal of diabetes and its complications（2023）

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摘要

Exogenous AGEs can mimic diabetic vasculopathy in vivo to some extent and increase profilin-1 expression in the target organs of diabetic complications. Blockade of profilin-1 attenuates vascular lesions and inflammatory reactions, suggesting its critical role in the metabolic memory mediated by AGEs.

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关键词

Advanced glycation end products (AGEs),Diabetic vasculopathy,Metabolic memory, inflammation, receptor for AGEs (RAGE), NF-κB,Profilin-1

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