Supplementary Figures 1 - 11 from AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial–Mesenchymal Transition and Suppresses Tumor Growth and Progression

PDF file - 1027K, (S1)Pipeline of the 3D structure prediction of pre-miR-21 hairpin loop. (S2) Real-time PCR assayed the miR-21 relative expression after the treatment of the top five compounds and As-miR-21. (S3) AC1MMYR2 selectively targets miR-21-high expression tumor cells (S4) AC1MMYR2 inhibited proliferation and induced apoptosis in LN229 and SGC7901 cancer cells. (S5) AC1MMYR2 suppressed the migration and invasion in LN229 and SGC7901 tumor cells. (S6) AC1MMYR2 displayed no toxicity to normal organs. (S7) AC1MMYR2 impacts on miR-21 and its functional targets expressions in MDA-MB-231 cells. (S8) AC1MMYR2 inhibited proliferation and induced apoptosis in MDA-MB-231 cells. (S9) AC1MMYR2 suppressed tumor cell invasion and migration in MDA-MB-231 cells. (S10) Histological evidences of the MCF-7 and MDA-MB-231 tumor phenotype. (S11) AC1MMYR2 mechanism of action was exhibited in schematic diagram.