Supplementary Figures 1 - 6, Table 1 from Interleukin-1β Promotes Skeletal Colonization and Progression of Metastatic Prostate Cancer Cells with Neuroendocrine Features

PDF file - 1996K, Supplementary Figure 1. Metastatic progression of different human prostate cancer cells in the skeleton of animal model. Supplementary Figure 2. Identification of pro-metastatic genes regulated by PDGFRa in PC3 cells. Supplementary Figure 3. Genes regulated by PDGFRa in DU-145 cells, which did not acquire bone-metastatic behavior upon exogenous expression of this receptor. Supplementary Figure 4. Two single-cell progenies of PC3-ML cells with high bone-metastatic potential. Supplementary Figure 5. Analysis of IL-1b expression and secretion from prostate cancer cells. Supplementary Figure 6. PDGFRa regulates Elafin and CXCL6 expression in prostate cancer cells. Supplementary Table 1. Contingency table of TMA data showing that prostate tumors with Gleason scores (≥7) expressed higher levels of the IL-1b protein as compared to tumors with lower Gleason scores (<7) (E). Chi-square = 33.08 and p<0.0001